Economic sanctions are tools used by countries to exert pressure on other countries and achieve their particular objectives. One of the most important threats of securing einvestment in Iran originates from the imposed sanctions on Iran in recent years that has affected the investment security in the Stock Market influencing at least 60 percent the Iranian community which necessitates codifying and providing strategies to confront the US sanctions on Iran’s Stock Market. Method: This research is of applied and developmental type from objective perspective and has analytical-descriptive nature with a mixed approach of discovery.The expert society includes economic security specialists with at least ten years of experience and responsibility in the fields of economy and stock market and expert samples were selected purposefully to the hypothetical saturation level. In order to analyze the collected data, we used SWAT Matrix and ranking average to categorize and prioterize the strategis. Findings: The most important strategies include: developing regulatory inteferrence instead of price inteferrence in order to increase the efficiency of the market and investment security, using Iran’s geographical expanse to develop trade and uphival of investment in less industial provinces, develoiping investment in small companies with the aim of mitigating the sanctions for these companies and so on. Key words: strategy, stock market, US sanctions